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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18 are 8
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5072
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    59.99 percent target mRNA inhibition
    22253019
    SM5073
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    60.63 percent target mRNA inhibition
    22253019
    SM5075
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    66.88 percent target mRNA inhibition
    22253019
    SM5076
    UCAUCACACUGAAUACCAAUU
    GTATTCAGTGTGATGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    58.32 percent target mRNA inhibition
    22253019
    SM5252
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    22.46 percent target mRNA inhibition
    22253019
    SM5253
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    23.44 percent target mRNA inhibition
    22253019
    SM5255
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    4.33 percent target mRNA inhibition
    22253019
    SM5256
    UCAUCACACUGAAUACCAAUU
    GTATTCAGTGTGATGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    14.87 percent target mRNA inhibition
    22253019